In addition, the ongoing controversy surrounding Trump and the fact that a woman is for the first time one of the major parties' presidential nominees has added interest to what was already a fascinating election season.
"I don't know. Honestly, I don't know what she's going to do. I don't know what her attitude is going to be," Trump recently said of Clinton. "I will treat her with great respect unless she treats me, you know, in a certain manner in which case, that will be the end of that."
Meanwhile, the former secretary of state has spent her time studying up on how to handle the "different Trumps" who could show up at the debate.
Clinton will seek to provoke Trump, who has less experience in questions of policy, so as to reveal his weaknesses and show off her own superior preparation, while the Republican will try to stress the need for a change.
Experts consider the first of the three scheduled debates to be key, given that it will set the tone and the narrative for the last stretch of the campaign leading up to the November 8 election.